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dc.contributor.authorHeo, Jae Ho-
dc.contributor.authorSeo, Han Na-
dc.contributor.authorChoe, Yun Jeong-
dc.contributor.authorKim, Sujin-
dc.contributor.authorOh, Chun Rim-
dc.contributor.authorKim, Young Deuk-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorChoo, Dong Joon-
dc.contributor.authorKim, Jungahn-
dc.contributor.authorLee, Jae Yeol-
dc.date.accessioned2024-01-20T23:02:15Z-
dc.date.available2024-01-20T23:02:15Z-
dc.date.created2021-09-03-
dc.date.issued2008-07-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133320-
dc.description.abstractIn order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectCALCIUM-CHANNELS-
dc.subjectIN-VITRO-
dc.subjectINHIBITION-
dc.subjectPROLIFERATION-
dc.subjectMIBEFRADIL-
dc.subjectEXPRESSION-
dc.subjectDRUG-
dc.titleT-type Ca2+ channel blockers suppress the growth of human cancer cells-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2008.06.034-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.14, pp.3899 - 3901-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume18-
dc.citation.number14-
dc.citation.startPage3899-
dc.citation.endPage3901-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000257640400014-
dc.identifier.scopusid2-s2.0-47249156681-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusCALCIUM-CHANNELS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusMIBEFRADIL-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusDRUG-
dc.subject.keywordAuthorT-type calcium channel blocker-
dc.subject.keywordAuthor3,4-dihydroquinazoline-
dc.subject.keywordAuthordoxorubicin-
dc.subject.keywordAuthoranti-cancer-
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