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dc.contributor.authorSeo, Han Na-
dc.contributor.authorChoi, Ja Youn-
dc.contributor.authorChoe, Yun Jeong-
dc.contributor.authorKim, Yoonjee-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorLee, So Ha-
dc.contributor.authorKim, Jungahn-
dc.contributor.authorJoo, Dong Jun-
dc.contributor.authorLee, Jae Yeol-
dc.date.accessioned2024-01-21T00:05:20Z-
dc.date.available2024-01-21T00:05:20Z-
dc.date.created2021-08-31-
dc.date.issued2007-11-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133990-
dc.description.abstractThe intensive SAR study of 3,.4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC50 = 41 +/- 1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date. (c) 2007 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectSTABLE ANGINA-
dc.subjectDERIVATIVES-
dc.subjectANTAGONISTS-
dc.subjectRELEASE-
dc.subjectDESIGN-
dc.subjectMUSCLE-
dc.subjectPAIN-
dc.titleDiscovery of potent T-type calcium channel blocker-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2007.08.070-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.21, pp.5740 - 5743-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume17-
dc.citation.number21-
dc.citation.startPage5740-
dc.citation.endPage5743-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000250287800001-
dc.identifier.scopusid2-s2.0-34548828834-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusSTABLE ANGINA-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusANTAGONISTS-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusMUSCLE-
dc.subject.keywordPlusPAIN-
dc.subject.keywordAuthorT-type calcium channel-
dc.subject.keywordAuthor3,4-dihydroquinazoline-
dc.subject.keywordAuthorkurtoxin-
dc.subject.keywordAuthorblocker-
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