DSpace at KISTKIST Article2007

Full metadata record

DC Field Value Language
dc.contributor.authorNam, Sang-Jip-
dc.contributor.authorKo, Hyunsil-
dc.contributor.authorJu, Moon Kyeong-
dc.contributor.authorHwang, Hoosang-
dc.contributor.authorChin, Jungwook-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorLee, Byoungchan-
dc.contributor.authorLee, Jaehwan-
dc.contributor.authorWon, Dong Hwan-
dc.contributor.authorChoi, Hyukjae-
dc.contributor.authorKo, Jaeyoung-
dc.contributor.authorShin, Kyoungjin-
dc.contributor.authorOh, Taekyung-
dc.contributor.authorKim, Seokho-
dc.contributor.authorRho, Jung-Rae-
dc.contributor.authorKang, Heonjoong-
dc.date.accessioned2024-01-21T00:05:48Z-
dc.date.available2024-01-21T00:05:48Z-
dc.date.created2021-09-02-
dc.date.issued2007-11-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134013-
dc.description.abstractThree new scalarane-based sesterterpenes, 1-3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC50 values of 2.4 and 24 mu M, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectNUCLEAR RECEPTOR-
dc.subjectLIGAND-
dc.subjectCHOLESTEROL-
dc.subjectEXPRESSION-
dc.titleScalarane sesterterpenes from a marine sponge of the genus spongia and their FXR antagonistic activity-
dc.typeArticle-
dc.identifier.doi10.1021/np070024k-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF NATURAL PRODUCTS, v.70, no.11, pp.1691 - 1695-
dc.citation.titleJOURNAL OF NATURAL PRODUCTS-
dc.citation.volume70-
dc.citation.number11-
dc.citation.startPage1691-
dc.citation.endPage1695-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000251179000001-
dc.identifier.scopusid2-s2.0-37249092686-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusNUCLEAR RECEPTOR-
dc.subject.keywordPlusLIGAND-
dc.subject.keywordPlusCHOLESTEROL-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordAuthorMarine Sponge-
dc.subject.keywordAuthorSpongia sp.-
dc.subject.keywordAuthorScalarane-
dc.subject.keywordAuthorSesterterpenes-
dc.subject.keywordAuthorFXR antagonist-
Appears in Collections:
KIST Article > 2007
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE