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dc.contributor.authorPark, Hyeong Beom-
dc.contributor.authorJo, Nam Hyun-
dc.contributor.authorHong, Joon Hee-
dc.contributor.authorChel, Jung Hoon-
dc.contributor.authorCho, Jung-Hyuck-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-21T00:31:24Z-
dc.date.available2024-01-21T00:31:24Z-
dc.date.created2021-09-02-
dc.date.issued2007-10-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134075-
dc.description.abstractThe synthesis of a new series of 1 beta-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem. and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectBETA-LACTAM ANTIBIOTICS-
dc.subjectANTIBACTERIAL ACTIVITY-
dc.subjectCARBAPENEM ANTIBIOTICS-
dc.subjectTHIENAMYCIN-
dc.subjectDERIVATIVES-
dc.titleSynthesis and in-vitro activity of novel 1 beta-methylcarbapenems having spiro[2,4]heptane moieties-
dc.typeArticle-
dc.identifier.doi10.1002/ardp.200700060-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.340, no.10, pp.530 - 537-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume340-
dc.citation.number10-
dc.citation.startPage530-
dc.citation.endPage537-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000250488600004-
dc.identifier.scopusid2-s2.0-35548999250-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBETA-LACTAM ANTIBIOTICS-
dc.subject.keywordPlusANTIBACTERIAL ACTIVITY-
dc.subject.keywordPlusCARBAPENEM ANTIBIOTICS-
dc.subject.keywordPlusTHIENAMYCIN-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordAuthorantibacterial activity-
dc.subject.keywordAuthor1 beta-methylcarbapenems-
dc.subject.keywordAuthorspiro[2,4]heptane-
dc.subject.keywordAuthorsubstituent effects-
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