Full metadata record

DC Field Value Language
dc.contributor.authorJeon, Sun Ah-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorPark, Woo-Kyu-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorKo, Soo Y.-
dc.contributor.authorCho, Yong Seo-
dc.contributor.authorKoh, Hun Yeong-
dc.contributor.authorPae, Ae Nim-
dc.date.accessioned2024-01-21T01:32:23Z-
dc.date.available2024-01-21T01:32:23Z-
dc.date.created2021-09-04-
dc.date.issued2007-02-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134641-
dc.description.abstractThe 5-HT6 antagonists are mainly related to the treatment of cognitive dysfunction or impairment associated with Alzheimer's disease and schizophrenia. There have been lots of efforts to develop 5-HT6 antagonists. As in our efforts, arylsulfonylpiperazine derivatives 1-3 were designed, synthesized and biologically evaluated against the human recombinant 5-HT6 serotonin receptor. Total 36 compounds were synthesized and the most active compound among the synthesized compounds is compound 2h with an IC50 value of 1.5 mu M. The compound 2h is novel as 5-HT6 receptor ligand and could act as lead for the novel 5-HT6 receptor ligands.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectSEROTONIN RECEPTORS-
dc.subjectADENYLATE-CYCLASE-
dc.subjectSTIMULATION-
dc.subjectBINDING-
dc.titleSynthesis and biological evaluation of arylsulfonylpiperazine derivatives as 5-HT6 receptor ligands-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.28, no.2, pp.285 - 291-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume28-
dc.citation.number2-
dc.citation.startPage285-
dc.citation.endPage291-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001040889-
dc.identifier.wosid000245197800025-
dc.identifier.scopusid2-s2.0-33847243659-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSEROTONIN RECEPTORS-
dc.subject.keywordPlusADENYLATE-CYCLASE-
dc.subject.keywordPlusSTIMULATION-
dc.subject.keywordPlusBINDING-
dc.subject.keywordAuthorserotonin-
dc.subject.keywordAuthor5-HT6 receptor-
dc.subject.keywordAuthorantagonists-
Appears in Collections:
KIST Article > 2007
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE