Synthesis and antibacterial activities of new 1 beta-methylcarbapenems having aminopyrimidinylthioether moiety

Abstract

The synthesis of new l beta-metbylcarbapenems 1a-d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described. All the compounds exhibited potent antibacterial activity. Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I). (c) 2006 Elsevier Masson SAS. All rights reserved.