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dc.contributor.authorLee, Jae Yeol-
dc.contributor.authorPark, Seong Jun-
dc.contributor.authorPark, Sung Jun-
dc.contributor.authorLee, Min Joo-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorSeo, Seon Hee-
dc.contributor.authorKim, Ki-Sun-
dc.date.accessioned2024-01-21T02:05:33Z-
dc.date.available2024-01-21T02:05:33Z-
dc.date.created2021-09-01-
dc.date.issued2006-10-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/135039-
dc.description.abstractThis paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range. (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCA2+ ENTRY-
dc.subjectPROLIFERATION-
dc.subjectCYCLE-
dc.titleGrowth inhibition of human cancer cells in vitro by T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2006.07.046-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.16, no.19, pp.5014 - 5017-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume16-
dc.citation.number19-
dc.citation.startPage5014-
dc.citation.endPage5017-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000240615400006-
dc.identifier.scopusid2-s2.0-33747334641-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCA2+ ENTRY-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusCYCLE-
dc.subject.keywordAuthorcancer cell-
dc.subject.keywordAuthorgrowth inhibition-
dc.subject.keywordAuthorT-type calcium channel blockers-
dc.subject.keywordAuthorcisplatin-
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