DSpace at KISTKIST Article2006

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dc.contributor.authorOh, Chang Hyun-
dc.contributor.authorKim, Jin Woo-
dc.contributor.authorHong, Joon Hee-
dc.date.accessioned2024-01-21T03:00:29Z-
dc.date.available2024-01-21T03:00:29Z-
dc.date.created2021-09-02-
dc.date.issued2006-07-
dc.identifier.issn1525-7770-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/135359-
dc.description.abstractNovel vinyl branched apiosyl nucleosides were synthesized in this study. Apiosyl sugar moiety was constructed by sequential ozonolysis and reductions. The bases (uracil and thymine) were efficiently coupled by glycosyl condensation procedure (persilyated base and TMSOTf). The antiviral activities of the synthesized compounds were evaluated against the HIV-1, HSV-1, HSV-2, and HCMV. Compound 10 beta displayed moderate anti-HIV activity (EC50 = 17.3 mu g/mL) without exhibiting any cytotoxicity up to 100 mu M.-
dc.languageEnglish-
dc.publisherTAYLOR & FRANCIS INC-
dc.subjectIMMUNODEFICIENCY-
dc.subjectPOTENT-
dc.titleSimple synthesis and anti-HIV activity of novel 3'-vinyl branched apiosyl pyrimidine nucleosides-
dc.typeArticle-
dc.identifier.doi10.1080/15257770600793869-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.25, no.8, pp.871 - 878-
dc.citation.titleNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS-
dc.citation.volume25-
dc.citation.number8-
dc.citation.startPage871-
dc.citation.endPage878-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000239453200005-
dc.identifier.scopusid2-s2.0-33746826080-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusIMMUNODEFICIENCY-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthorantiviral agents-
dc.subject.keywordAuthorapiosyl nucleoside-
dc.subject.keywordAuthorozonolysis-
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