DSpace at KISTKIST Article2005

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dc.contributor.authorLee, KS-
dc.contributor.authorKang, YK-
dc.contributor.authorYoo, KH-
dc.contributor.authorKim, DC-
dc.contributor.authorShin, KJ-
dc.contributor.authorPaik, YS-
dc.contributor.authorKim, DJ-
dc.date.accessioned2024-01-21T05:38:54Z-
dc.date.available2024-01-21T05:38:54Z-
dc.date.created2021-09-03-
dc.date.issued2005-01-03-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/136836-
dc.description.abstractThe synthesis of novel 1beta-methylcarbapenems 1a,b having sodium 5-(3- and 5-carboxylic acid)isoxazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. The selected sodium 3-carboxylic acid derivative la possessed excellent DHP-I stability and advanced pharmacokinetic parameters in comparison with 2 and meropenem. (C) 2004 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleNovel 1 beta-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2004.09.092-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.15, no.1, pp.231 - 234-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage231-
dc.citation.endPage234-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000225773600044-
dc.identifier.scopusid2-s2.0-9644276816-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
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KIST Article > 2005
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