자외선 표면개질에 의한 술폰산화 폴리에틸렌옥시드가 그라프트된 의료용기능성 셀루로오즈의 제조

Abstract

New water-soluble and photoreactive sulfonated poly(ethylene oxide) (PEO, MW = 1,000) containing 4-azidobenzaldehyde-2-sodium sulfonate (ABS) (ABS-PEO-SO3) was synthesized and then grafted on cellulose (Cell) by UV irradiation to yield functional PEO-SO3-grafted cellulose (Cell-PEO-SO3) to use for biomedical materials. The surface-modified cellulose was made by first coating aqueous solution of 20% ABS-PEO-SO3 on cellulose film for 24 h, followed by drying, and then UV irradiation (400 W) for 10 min. It was confirmed that ABS-PEO-SO3 was synthesized well from the results of elemental analysis, FTIR, and 1H-NMR. The surface properties of the modified cellulose were evaluated by measuring ATR-FTIR, ESCA, SEM, and water contact angle. As compared to cellulose control, the modified cellulose demonstrated similar smoothness and much increase in hydrophilicity (complete wetting) due to the grafting of hydrophilic ABS-PEO-SO3. The interaction of the modified cellulose and platelet was examined by platelet adhesion test. The modified cellulose showed less adhesion and shape change of platelets than cellulose control, indicating the enhanced blood compatibility. Therefore, this functional Cell-PEO-SO3 is expected to be useful for blood contacting materials and artificial organs including a hemodialyzer for an artificial kidney.