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Effects of the extracts from Pelvetia siliquosa on metabolism regulation in rats

Authors
Lee, S.; Lee, Y.S.; Jung, S.H.; Shin, K.H.; Kim, B.-K.
Issue Date
2004-09
Citation
Korean Journal of Pharmacognosy, v.35, no.3, pp.203 - 206
Abstract
Effects of the EtOH extract from Pelvetia siliquosa on CCl 4-induced hepatotoxicity as well as streptozotocin-induced diabetes in rats were investigated. The EtOH extract was found to cause an inhibition of the rise in the transaminase activities in CCl4-intoxicated rats. Also, the EtOH extract exhibited a rat lens aldose reductase inhibition in vitro and showed an inhibition of not only glucose concentrations but also sorbitol accumulations in the lenses, red blood cells and sciatic nerves in the STZ-induced diabetic rats in vivo. These results suggested that this plant might possess hepatoprotective and anti-diabetic activities.
Keywords
alcohol; aldehyde reductase; aminotransferase; carbon tetrachloride; epalrestat; glucose; liver enzyme; metformin; pelvetia siliquosa extract; plant extract; silymarin; sorbitol; unclassified drug; animal cell; animal model; animal tissue; antidiabetic activity; article; carbohydrate metabolism; controlled study; drug activity; drug effect; enzyme activity; enzyme inhibition; erythrocyte; glucose metabolism; lens; liver protection; liver toxicity; medicinal plant; metabolic regulation; nonhuman; Pelevetia siliquosa; rat; sciatic nerve; streptozocin diabetes; alcohol; aldehyde reductase; aminotransferase; carbon tetrachloride; epalrestat; glucose; liver enzyme; metformin; pelvetia siliquosa extract; plant extract; silymarin; sorbitol; unclassified drug; animal cell; animal model; animal tissue; antidiabetic activity; article; carbohydrate metabolism; controlled study; drug activity; drug effect; enzyme activity; enzyme inhibition; erythrocyte; glucose metabolism; lens; liver protection; liver toxicity; medicinal plant; metabolic regulation; nonhuman; Pelevetia siliquosa; rat; sciatic nerve; streptozocin diabetes; Diabetes; Fucaceae; Hepatotoxicity; Pelvetia siliquosa
ISSN
0253-3073
URI
https://pubs.kist.re.kr/handle/201004/137295
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KIST Article > 2004
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