Full metadata record
DC Field | Value | Language |
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dc.contributor.author | An, JJ | - |
dc.contributor.author | Bae, MH | - |
dc.contributor.author | Cho, SR | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Choi, SH | - |
dc.contributor.author | Lee, BH | - |
dc.contributor.author | Shin, HS | - |
dc.contributor.author | Kim, YN | - |
dc.contributor.author | Park, KW | - |
dc.contributor.author | Borrelli, E | - |
dc.contributor.author | Baik, JH | - |
dc.date.accessioned | 2024-01-21T07:14:06Z | - |
dc.date.available | 2024-01-21T07:14:06Z | - |
dc.date.created | 2021-09-02 | - |
dc.date.issued | 2004-04 | - |
dc.identifier.issn | 1044-7431 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/137738 | - |
dc.description.abstract | The levels of glutamic acid decarboxylase (GAD) were strongly increased in the cortex and the striatum in dopamine D2 receptors null (D2R-/-) mice, which show a significant locomotor impairment. In this study, the effects of different GABAergic drugs on locomotor,activity were analyzed in D2R-/- mice. After administering muscimol (1 mg/kg), a GABA(A) receptor agonist, the D2R-/- mice showed increased locomotor activity up to 200%. When the muscimol dose was increased (4-6 mg/kg), the D2R-/- mice exhibited seizure-like behavior, and the electroencephalographic (EEG) recordings during these behaviors showed a high amplitude rhythmic epileptiform activity in these mice. In situ hybridization showed that after injecting muscimol in the D2R-/- mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation. These results suggest that the absence of D2R alters the GABAergic neurotransmission, specifically on GABA(A)-receptor mediated signaling, and stimulating the GABA(A) receptor can reverse the dysfunction of GABAergic inhibition in the motor circuits in the basal ganglia. (C) 2004 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | BASAL GANGLIA | - |
dc.subject | STRIATOPALLIDAL NEURONS | - |
dc.subject | LOCOMOTOR IMPAIRMENT | - |
dc.subject | SUBTHALAMIC NEURONS | - |
dc.subject | GABA(A) RECEPTORS | - |
dc.subject | RAT HIPPOCAMPUS | - |
dc.subject | PARS RETICULATA | - |
dc.subject | IN-VITRO | - |
dc.subject | NGFI-A | - |
dc.title | Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.mcn.2003.12.010 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR NEUROSCIENCE, v.25, no.4, pp.732 - 741 | - |
dc.citation.title | MOLECULAR AND CELLULAR NEUROSCIENCE | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 732 | - |
dc.citation.endPage | 741 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000220852400016 | - |
dc.identifier.scopusid | 2-s2.0-11144356288 | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | STRIATOPALLIDAL NEURONS | - |
dc.subject.keywordPlus | LOCOMOTOR IMPAIRMENT | - |
dc.subject.keywordPlus | SUBTHALAMIC NEURONS | - |
dc.subject.keywordPlus | GABA(A) RECEPTORS | - |
dc.subject.keywordPlus | RAT HIPPOCAMPUS | - |
dc.subject.keywordPlus | PARS RETICULATA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | NGFI-A | - |
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