DSpace at KISTKIST Article2004

Full metadata record

DC Field Value Language
dc.contributor.authorPark, JH-
dc.contributor.authorMin, HY-
dc.contributor.authorKim, SS-
dc.contributor.authorLee, JY-
dc.contributor.authorLee, SK-
dc.contributor.authorLee, YS-
dc.date.accessioned2024-01-21T07:42:44Z-
dc.date.available2024-01-21T07:42:44Z-
dc.date.created2021-09-02-
dc.date.issued2004-01-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/137988-
dc.description.abstract4'-Dihydroxylated styrylquinazolines (2 a-c), 3'-hydroxylated styrylquinazolines 3', (2 h, 2 i), and 3'-acetoxy-styrylquinazolines (2 j, 2 k) exhibited good inhibitory effects of PGE(2) production by COX-2 with a range of IC50 values of 1.19 similar to 3.56 muM. The potencies were comparable or better than that of the representative stilbene resveratrol (IC50 = 3.07 muM). These results indicate that styrylquinazolines can be considered as potential resveratrol analogues in the modulation of prostaglandin production by COX-2.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectRESVERATROL-
dc.subjectDERIVATIVES-
dc.subjectPOTENT-
dc.titleStyrylquinazolines: A new class of inhibitors on prostaglandin E-2 production in lipopolysaccharide-activated macrophage cells-
dc.typeArticle-
dc.identifier.doi10.1002/ardp.200300791-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.337, no.1, pp.20 - 24-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume337-
dc.citation.number1-
dc.citation.startPage20-
dc.citation.endPage24-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000188857200003-
dc.identifier.scopusid2-s2.0-1242269414-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusRESVERATROL-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthorstyrylquinazoline-
dc.subject.keywordAuthorprostaglandin E-2 (PGE(2))-
dc.subject.keywordAuthorcyclooxygenase-
dc.subject.keywordAuthorCOX-
dc.subject.keywordAuthorresveratrol-
dc.subject.keywordAuthorinflammation-
dc.subject.keywordAuthorchemoprevention-
dc.subject.keywordAuthorperkin condensation-
Appears in Collections:
KIST Article > 2004
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE