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dc.contributor.authorLee, BS-
dc.contributor.authorChu, S-
dc.contributor.authorLee, KC-
dc.contributor.authorLee, BS-
dc.contributor.authorChi, DY-
dc.contributor.authorChoe, YS-
dc.contributor.authorKirn, SE-
dc.contributor.authorSong, YS-
dc.contributor.authorJin, C-
dc.date.accessioned2024-01-21T08:03:04Z-
dc.date.available2024-01-21T08:03:04Z-
dc.date.created2021-09-03-
dc.date.issued2003-11-17-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138081-
dc.description.abstract3-(3-[F-18]Fluoropropyl)-6-nitroquipazine ([F-18]FPNQ) as a 5-HT transporter imaging agents was designed, synthesized, and evaluated. FPNQ was selected due to its potent in vitro biological activity (K-i = 0.32 nM) in rat brain cortical membranes. The F-18-labeled FPNQ was prepared by reaction of the propyl mesylate as a precursor with tetra-n-butylammonium [F-18]fluoride generated under NCA conditions. The precursor mesylate was synthesized from commercially available hydrocarbostyril in nine steps in 21% overall yield. The specific activity of the [F-18]FPNQ determined by radioreceptor assay was 27.0 GBq/mumol. Tissue distribution studies in mice showed the highest uptake in the frontal cortex (5.79 %ID/g) at 60 min post-injection. (C) 2003 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectPOSITRON-EMISSION-TOMOGRAPHY-
dc.subject5-HYDROXYTRYPTAMINE UPTAKE COMPLEX-
dc.subjectDOPAMINE TRANSPORTER-
dc.subjectH-3 6-NITROQUIPAZINE-
dc.subjectIN-VIVO-
dc.subjectI-125 5-IODO-6-NITROQUIPAZINE-
dc.subjectPARKINSONS-DISEASE-
dc.subjectSELECTIVE LIGAND-
dc.subjectUPTAKE SITES-
dc.subjectRAT-BRAIN-
dc.titleSyntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[F-18]fluoropropyl)-6-nitroquipazine-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2003.09.009-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.11, no.23, pp.4949 - 4958-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume11-
dc.citation.number23-
dc.citation.startPage4949-
dc.citation.endPage4958-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000186614400011-
dc.identifier.scopusid2-s2.0-0242298240-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPOSITRON-EMISSION-TOMOGRAPHY-
dc.subject.keywordPlus5-HYDROXYTRYPTAMINE UPTAKE COMPLEX-
dc.subject.keywordPlusDOPAMINE TRANSPORTER-
dc.subject.keywordPlusH-3 6-NITROQUIPAZINE-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusI-125 5-IODO-6-NITROQUIPAZINE-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusSELECTIVE LIGAND-
dc.subject.keywordPlusUPTAKE SITES-
dc.subject.keywordPlusRAT-BRAIN-
dc.subject.keywordAuthorserotonin transporter-
dc.subject.keywordAuthor6-nitroquipazine analogues-
dc.subject.keywordAuthorbinding affinities-
dc.subject.keywordAuthorimaging agent-
dc.subject.keywordAuthor3-(3-[18F]fluoropropyl)-6-nitroquipazine-
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