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Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Authors
Jeong, LS; Moon, HR; Park, JC; Shin, DH; Choi, WJ; Lee, KM; Kim, HO; Chun, MW; Kim, HD; Kim, JH
Issue Date
2003-10
Publisher
MARCEL DEKKER INC
Citation
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.22, no.5-8, pp.589 - 592
Abstract
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
Keywords
halo-neplanocin A; S-Adenosylhomocysteine hydrolase; mechanism-based inhibitor
ISSN
1525-7770
URI
https://pubs.kist.re.kr/handle/201004/138218
DOI
10.1081/NCN-120021961
Appears in Collections:
KIST Article > 2003
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