Full metadata record

DC Field Value Language
dc.contributor.authorWeisel, CP-
dc.contributor.authorPark, SS-
dc.contributor.authorPyo, H-
dc.contributor.authorMohan, K-
dc.contributor.authorWitz, G-
dc.date.accessioned2024-01-21T08:14:18Z-
dc.date.available2024-01-21T08:14:18Z-
dc.date.created2021-09-03-
dc.date.issued2003-09-
dc.identifier.issn1053-4245-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138290-
dc.description.abstractThe use of stable, isotopically labeled compounds in controlled exposure experiments at environmentally relevant levels allows for the distinguishing of urinary metabolites associated with known exposure from background levels generally present in the urine. Exposures of volunteers to C-13-benzene for 2 h at 4 +/- 10 p.p.b. were conducted after <LF>obtaining informed consent, and urinary phenol, catechol, hydroquinone and trans, trans-muconic acid were measured. Each isotopically labeled urinary metabolite was determined in the presence of significantly higher concentrations of the unlabeled metabolite. Following exposure, free and acid hydrolyzed phenol, acid hydrolyzed catechol and hydroquinone, and free trans, trans-muconic acid were determined by GC/MS. The percentage of trans, trans-muconic acid excreted was higher than reported following exposure at occupational levels. The use of isotopically labeled compounds has the potential to investigate the metabolism of common environmental contaminants for validation of toxicokinetic models and improve risk extrapolation from high concentration occupational exposures and animal studies to environmentally relevant pollutant levels.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectVOLATILE ORGANIC-COMPOUNDS-
dc.subjectTRANS-MUCONIC ACID-
dc.subjectTRANS,TRANS-MUCONIC ACID-
dc.subjectOCCUPATIONAL EXPOSURE-
dc.subjectBIOLOGICAL INDICATOR-
dc.subjectURINARY METABOLITE-
dc.subjectGAS-CHROMATOGRAPHY-
dc.subjectT,T-MUCONIC ACID-
dc.subjectB6C3F1 MICE-
dc.subjectBIOMARKERS-
dc.titleUse of stable isotopically labeled benzene to evaluate environmental exposures-
dc.typeArticle-
dc.identifier.doi10.1038/sj.jea.7500285-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY, v.13, no.5, pp.393 - 402-
dc.citation.titleJOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY-
dc.citation.volume13-
dc.citation.number5-
dc.citation.startPage393-
dc.citation.endPage402-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000185335400007-
dc.identifier.scopusid2-s2.0-0142216256-
dc.relation.journalWebOfScienceCategoryEnvironmental Sciences-
dc.relation.journalWebOfScienceCategoryPublic, Environmental & Occupational Health-
dc.relation.journalWebOfScienceCategoryToxicology-
dc.relation.journalResearchAreaEnvironmental Sciences & Ecology-
dc.relation.journalResearchAreaPublic, Environmental & Occupational Health-
dc.relation.journalResearchAreaToxicology-
dc.type.docTypeArticle-
dc.subject.keywordPlusVOLATILE ORGANIC-COMPOUNDS-
dc.subject.keywordPlusTRANS-MUCONIC ACID-
dc.subject.keywordPlusTRANS,TRANS-MUCONIC ACID-
dc.subject.keywordPlusOCCUPATIONAL EXPOSURE-
dc.subject.keywordPlusBIOLOGICAL INDICATOR-
dc.subject.keywordPlusURINARY METABOLITE-
dc.subject.keywordPlusGAS-CHROMATOGRAPHY-
dc.subject.keywordPlusT,T-MUCONIC ACID-
dc.subject.keywordPlusB6C3F1 MICE-
dc.subject.keywordPlusBIOMARKERS-
dc.subject.keywordAuthorbenzene-
dc.subject.keywordAuthorstable isotope-
dc.subject.keywordAuthorcontrolled exposure-
dc.subject.keywordAuthorenvironmental exposure-
dc.subject.keywordAuthorurinary metabolites-
dc.subject.keywordAuthorbiomarkers-
Appears in Collections:
KIST Article > 2003
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE