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dc.contributor.authorXu, YW-
dc.contributor.authorZhao, GS-
dc.contributor.authorShin, CG-
dc.contributor.authorZang, HC-
dc.contributor.authorLee, CK-
dc.contributor.authorLee, YS-
dc.date.accessioned2024-01-21T08:15:32Z-
dc.date.available2024-01-21T08:15:32Z-
dc.date.created2021-09-03-
dc.date.issued2003-08-15-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138312-
dc.description.abstractHIV-1 integrase (IN) is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. In the present study, we have designed, synthesized and tested a series of caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors. Among these compounds, we found that HIV integrase inhibitory activities of compounds III-3 and III-4 were more potent than L-chicoric acid (IC50 = 11.8 mug/mL) and others were comparable to L-chicoric acid. Furthermore, the structure-activity relationships of these compounds were studied. The information gathered from this paper will be useful in the development and design of HIV-1 integrase inhibitors in the future. (C) 2003 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectVIRUS TYPE-1 INTEGRASE-
dc.subjectDICAFFEOYLTARTARIC ACIDS-
dc.subjectPOTENT INHIBITORS-
dc.subjectIDENTIFICATION-
dc.subjectREPLICATION-
dc.subjectANALOGS-
dc.subjectINVITRO-
dc.subjectPROTEIN-
dc.titleCaffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors-
dc.typeArticle-
dc.identifier.doi10.1016/S0968-0896(03)00372-9-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.11, no.17, pp.3589 - 3593-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume11-
dc.citation.number17-
dc.citation.startPage3589-
dc.citation.endPage3593-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000184865100004-
dc.identifier.scopusid2-s2.0-0043125683-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusVIRUS TYPE-1 INTEGRASE-
dc.subject.keywordPlusDICAFFEOYLTARTARIC ACIDS-
dc.subject.keywordPlusPOTENT INHIBITORS-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusREPLICATION-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusINVITRO-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordAuthorAIDS-
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