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dc.contributor.authorHong, JH-
dc.contributor.authorOh, CH-
dc.contributor.authorCho, JH-
dc.date.accessioned2024-01-21T08:15:40Z-
dc.date.available2024-01-21T08:15:40Z-
dc.date.created2021-09-03-
dc.date.issued2003-08-04-
dc.identifier.issn0040-4020-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138314-
dc.description.abstractThis paper describes the racemic and stereoselective synthetic route for a novel 6'(alpha)-hydroxy-carbovir from a simple acyclic precursor. Solketal. The relative stereochemistry of the target nucleosides was successfully controlled by a sequential stereoselective glycolate Claisen rearrangement followed by a ring-closing metathesis (RCM). Adenine and cytosine were coupled using a Pd(0) catalyzed allylic alkylation strategy in a high regio- and stereoselective manner. (C) 2003 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectADENOSYLHOMOCYSTEINE HYDROLASE INHIBITORS-
dc.subjectENOLATE CLAISEN REARRANGEMENT-
dc.subjectHUMAN-IMMUNODEFICIENCY-VIRUS-
dc.subjectCARBOCYCLIC NUCLEOSIDES-
dc.subjectS-ADENOSYLHOMOCYSTEINE-
dc.subjectEFFICIENT SYNTHESIS-
dc.subjectCLOSING METATHESIS-
dc.subjectANTIVIRAL ACTIVITY-
dc.subjectMECHANISM-
dc.subject7-BETA-D-RIBOFURANOSYLPURINES-
dc.titleStereocontrolled synthesis of novel 6 '(alpha)-hydroxy carbovir analogues-
dc.typeArticle-
dc.identifier.doi10.1016/S0040-4020(03)00986-4-
dc.description.journalClass1-
dc.identifier.bibliographicCitationTETRAHEDRON, v.59, no.32, pp.6103 - 6108-
dc.citation.titleTETRAHEDRON-
dc.citation.volume59-
dc.citation.number32-
dc.citation.startPage6103-
dc.citation.endPage6108-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000184593700014-
dc.identifier.scopusid2-s2.0-0042847390-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusADENOSYLHOMOCYSTEINE HYDROLASE INHIBITORS-
dc.subject.keywordPlusENOLATE CLAISEN REARRANGEMENT-
dc.subject.keywordPlusHUMAN-IMMUNODEFICIENCY-VIRUS-
dc.subject.keywordPlusCARBOCYCLIC NUCLEOSIDES-
dc.subject.keywordPlusS-ADENOSYLHOMOCYSTEINE-
dc.subject.keywordPlusEFFICIENT SYNTHESIS-
dc.subject.keywordPlusCLOSING METATHESIS-
dc.subject.keywordPlusANTIVIRAL ACTIVITY-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlus7-BETA-D-RIBOFURANOSYLPURINES-
dc.subject.keywordAuthorcarbocyclic nucleosides-
dc.subject.keywordAuthorglycolate Claisen rearrangement-
dc.subject.keywordAuthorRCM-
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