DSpace at KISTKIST Article2003

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dc.contributor.authorKang, YK-
dc.contributor.authorLee, KS-
dc.contributor.authorYoo, KH-
dc.contributor.authorShin, KJ-
dc.contributor.authorKim, DC-
dc.contributor.authorLee, CS-
dc.contributor.authorKong, JY-
dc.contributor.authorKim, DJ-
dc.date.accessioned2024-01-21T09:14:18Z-
dc.date.available2024-01-21T09:14:18Z-
dc.date.created2021-09-03-
dc.date.issued2003-02-10-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138823-
dc.description.abstractThe synthesis of novel 1beta-methylcarbapenems la,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative la exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem. (C) 2002 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleSynthesis and biological evaluation of novel 1 beta-methylcarbapenems with isothiazoloethenyl side chains-
dc.typeArticle-
dc.identifier.doi10.1016/S0960-894X(02)00948-4-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.3, pp.463 - 466-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage463-
dc.citation.endPage466-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000180957100032-
dc.identifier.scopusid2-s2.0-0037328479-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordAuthor1 β -methylcarbapenems-
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