DSpace at KISTKIST Article2002

Full metadata record

DC Field Value Language
dc.contributor.authorLee, JY-
dc.contributor.authorOh, CH-
dc.contributor.authorKo, OH-
dc.contributor.authorHong, JH-
dc.date.accessioned2024-01-21T09:39:11Z-
dc.date.available2024-01-21T09:39:11Z-
dc.date.created2022-01-10-
dc.date.issued2002-12-
dc.identifier.issn1525-7770-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/139005-
dc.description.abstractA series of novel acyclic nucleosides 10, 11, 21, and 22 were synthesized efficiently starting from D-lactose. The condensation of the mesylate 5 and 16 with an adenine and cytosine base under standard nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) afforded a series of acyclic novel nucleosides. Compound 21 displayed moderate anti-HCMV activity in the AD-169 cells (EC50 = 18.5 mug/mL) without exhibiting any cytotoxicity up to 100 muM.-
dc.languageEnglish-
dc.publisherTAYLOR & FRANCIS INC-
dc.subjectSIMPLEX VIRUS TYPE-1-
dc.subjectANTIVIRAL ACTIVITY-
dc.subjectANALOGS-
dc.titleSynthesis and anti-HCMV activity of novel acyclic nucleosides-
dc.typeArticle-
dc.identifier.doi10.1081/NCN-120015727-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.21, no.10, pp.709 - 721-
dc.citation.titleNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS-
dc.citation.volume21-
dc.citation.number10-
dc.citation.startPage709-
dc.citation.endPage721-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000179627900007-
dc.identifier.scopusid2-s2.0-1842869980-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusSIMPLEX VIRUS TYPE-1-
dc.subject.keywordPlusANTIVIRAL ACTIVITY-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordAuthornucleoside-
Appears in Collections:
KIST Article > 2002
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE