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dc.contributor.authorLee, JY-
dc.contributor.authorPARK YONG KYU-
dc.contributor.authorSeo, SH-
dc.contributor.authorYang, BS-
dc.contributor.authorPark, H-
dc.contributor.authorLee, YS-
dc.date.accessioned2024-01-21T09:40:51Z-
dc.date.available2024-01-21T09:40:51Z-
dc.date.created2021-09-01-
dc.date.issued2002-12-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/139036-
dc.description.abstractWith the aim of developing inhibitors of EGFR tyrosine kinase, the 7-methoxymethyl-[1,4]dioxano[2,3-g]quinazolines (3a-b) and 7-mono- or di-alkylaminomethyl-[1,4]dioxano[2,3-g]quinazolines (4a-i) were prepared and evaluated for the inhibition of EGFR tyrosine kinase and the growth inhibition of human tumor cell lines. Among them, compounds 4d and 4h showed potencies against both EGFR tyrosine and the A431 cell line similar to that of PD153035 with greater aqueous solubilities of their HCI salts.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.title7-substituted-[1,4]dioxano[2,3-g]quinazolines as inhibitors of epidermal growth factor receptor kinase-
dc.typeArticle-
dc.identifier.doi10.1002/ardp.200290003-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.335, no.10, pp.487 - 494-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume335-
dc.citation.number10-
dc.citation.startPage487-
dc.citation.endPage494-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000180492600004-
dc.identifier.scopusid2-s2.0-0036964279-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBINDING-SITE INHIBITORS-
dc.subject.keywordPlusTYROSINE KINASE-
dc.subject.keywordAuthorEGFR-
dc.subject.keywordAuthortyrosine kinase-
dc.subject.keywordAuthorinhibitor-
dc.subject.keywordAuthorwater solubility-
dc.subject.keywordAuthordioxane-
dc.subject.keywordAuthorquinazoline-
dc.subject.keywordAuthorA431-
dc.subject.keywordAuthorantitumor-
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