Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, CH | - |
dc.contributor.author | Dong, HG | - |
dc.contributor.author | Cho, HW | - |
dc.contributor.author | Park, SJ | - |
dc.contributor.author | Hong, JH | - |
dc.contributor.author | Baek, DJ | - |
dc.contributor.author | Cho, JH | - |
dc.date.accessioned | 2024-01-21T10:40:05Z | - |
dc.date.available | 2024-01-21T10:40:05Z | - |
dc.date.created | 2022-01-10 | - |
dc.date.issued | 2002-05 | - |
dc.identifier.issn | 0365-6233 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/139562 | - |
dc.description.abstract | The synthesis of new series of 1beta-methylcarbapenems having a 2,2-disubstituted-1,3-diazabicyclo[3.3.0]octan- and -[4.3.0]nonan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent of the bicyclic ring was investigated. A particular compound (16f) bearing a hydroxymethyl group showed the most potent antibacterial activity and the compound (17a) with a 1,3-diazabicyclo[4.3.0]nonane moiety exhibited excellent stability against renal dehydropeptidase-I (DHP-I) to Meropenem. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | CARBAPENEM | - |
dc.title | Synthesis and antibacterial activity of 1 beta-methylcarbapenems having a 2,2-disubstituted-1,3-diazabicyclo[3.3.0]octan-4-one moiety and related compounds. Part III | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/1521-4184(200205)335:5<200::AID-ARDP200>3.0.CO;2-X | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | ARCHIV DER PHARMAZIE, v.335, no.5, pp.200 - 206 | - |
dc.citation.title | ARCHIV DER PHARMAZIE | - |
dc.citation.volume | 335 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 200 | - |
dc.citation.endPage | 206 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000177268200003 | - |
dc.identifier.scopusid | 2-s2.0-0036021860 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CARBAPENEM | - |
dc.subject.keywordAuthor | carbapenem | - |
dc.subject.keywordAuthor | antibacterial activity | - |
dc.subject.keywordAuthor | substituent effect | - |
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