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dc.contributor.authorOh, CH-
dc.contributor.authorDong, HG-
dc.contributor.authorCho, HW-
dc.contributor.authorPark, SJ-
dc.contributor.authorHong, JH-
dc.contributor.authorBaek, DJ-
dc.contributor.authorCho, JH-
dc.date.accessioned2024-01-21T10:40:05Z-
dc.date.available2024-01-21T10:40:05Z-
dc.date.created2022-01-10-
dc.date.issued2002-05-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/139562-
dc.description.abstractThe synthesis of new series of 1beta-methylcarbapenems having a 2,2-disubstituted-1,3-diazabicyclo[3.3.0]octan- and -[4.3.0]nonan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent of the bicyclic ring was investigated. A particular compound (16f) bearing a hydroxymethyl group showed the most potent antibacterial activity and the compound (17a) with a 1,3-diazabicyclo[4.3.0]nonane moiety exhibited excellent stability against renal dehydropeptidase-I (DHP-I) to Meropenem.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectCARBAPENEM-
dc.titleSynthesis and antibacterial activity of 1 beta-methylcarbapenems having a 2,2-disubstituted-1,3-diazabicyclo[3.3.0]octan-4-one moiety and related compounds. Part III-
dc.typeArticle-
dc.identifier.doi10.1002/1521-4184(200205)335:5<200::AID-ARDP200>3.0.CO;2-X-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.335, no.5, pp.200 - 206-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume335-
dc.citation.number5-
dc.citation.startPage200-
dc.citation.endPage206-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000177268200003-
dc.identifier.scopusid2-s2.0-0036021860-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCARBAPENEM-
dc.subject.keywordAuthorcarbapenem-
dc.subject.keywordAuthorantibacterial activity-
dc.subject.keywordAuthorsubstituent effect-
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