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dc.contributor.authorOh, CH-
dc.contributor.authorKim, HK-
dc.contributor.authorLee, SC-
dc.contributor.authorOh, C-
dc.contributor.authorYang, BS-
dc.contributor.authorRhee, HJ-
dc.contributor.authorCho, JH-
dc.date.accessioned2024-01-21T11:37:34Z-
dc.date.available2024-01-21T11:37:34Z-
dc.date.created2022-01-10-
dc.date.issued2001-11-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/140063-
dc.description.abstractIn this study, C-2, C-8, N-9 substituted 6-(3-chloroanilino)purine derivatives were synthesized and their inhibitory effects on cyclin-dependent kinases (CDK2, 4) as well as their cytotoxicities were evaluated. The effects of substituents at the C-2, C-8, and N-9 positions of the substituted purine were investigated. Among the compounds tested, [6-(3-chloroanilino)-2-(2-hydroxymethyl-4-hydroxypyrrolidyl)-9-isopropylpurine] (4h) was the most active inhibitor of CDK2 with IC50 of 0.3 muM, i.e. a two-fold increased inhibitory activity as compared to roscovitine. Results from structure-activity relationship studies should allow the design of more potent and selective CDK2 inhibitors, which may provide an effective therapy for cancer or other CDK-dependent diseases.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectSELECTIVE INHIBITOR-
dc.subjectPURINE ANALOGS-
dc.subjectCDK INHIBITORS-
dc.subjectCDC2 KINASE-
dc.subjectROSCOVITINE-
dc.subjectCANCER-
dc.subjectPOTENT-
dc.titleSynthesis and biological properties of C-2, C-8, N-9 substituted 6-(3-chloroanilino)purine derivatives as cyclin-dependent kinase inhibitors. Part II-
dc.typeArticle-
dc.identifier.doi10.1002/1521-4184(200112)334:11<345::AID-ARDP345>3.0.CO;2-1-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.334, no.11, pp.345 - 350-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume334-
dc.citation.number11-
dc.citation.startPage345-
dc.citation.endPage350-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000173080100002-
dc.identifier.scopusid2-s2.0-0035668305-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSELECTIVE INHIBITOR-
dc.subject.keywordPlusPURINE ANALOGS-
dc.subject.keywordPlusCDK INHIBITORS-
dc.subject.keywordPlusCDC2 KINASE-
dc.subject.keywordPlusROSCOVITINE-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthorCDK2 inhibitor-
dc.subject.keywordAuthorm-chloroanilinopurine-
dc.subject.keywordAuthorcell cycle regulation-
dc.subject.keywordAuthorantiproliferative effect-
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KIST Article > 2001
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