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dc.contributor.authorLee, KY-
dc.contributor.authorKim, JH-
dc.contributor.authorKwon, IC-
dc.contributor.authorJeong, SY-
dc.date.accessioned2024-01-21T13:09:05Z-
dc.date.available2024-01-21T13:09:05Z-
dc.date.created2021-09-05-
dc.date.issued2000-12-
dc.identifier.issn0303-402X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/140906-
dc.description.abstractA novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregated suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).-
dc.languageEnglish-
dc.publisherSPRINGER-VERLAG-
dc.subjectBLOCK-COPOLYMER MICELLES-
dc.subjectHYDROGEL NANOPARTICLE-
dc.subjectPHYSICAL ENTRAPMENT-
dc.subjectDELIVERY-
dc.subjectDRUG-
dc.subjectSTABILIZATION-
dc.subjectCOMPLEXATION-
dc.subjectDERIVATIVES-
dc.subjectBLOOD-
dc.titleSelf-aggregates of deoxycholic acid modified chitosan as a novel carrier of adriamycin-
dc.typeArticle-
dc.identifier.doi10.1007/s003960000389-
dc.description.journalClass1-
dc.identifier.bibliographicCitationCOLLOID AND POLYMER SCIENCE, v.278, no.12, pp.1216 - 1219-
dc.citation.titleCOLLOID AND POLYMER SCIENCE-
dc.citation.volume278-
dc.citation.number12-
dc.citation.startPage1216-
dc.citation.endPage1219-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000166036800012-
dc.identifier.scopusid2-s2.0-0033638749-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryPolymer Science-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaPolymer Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusBLOCK-COPOLYMER MICELLES-
dc.subject.keywordPlusHYDROGEL NANOPARTICLE-
dc.subject.keywordPlusPHYSICAL ENTRAPMENT-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusDRUG-
dc.subject.keywordPlusSTABILIZATION-
dc.subject.keywordPlusCOMPLEXATION-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusBLOOD-
dc.subject.keywordAuthorchitosan-
dc.subject.keywordAuthordeoxycholic acid-
dc.subject.keywordAuthorself-aggregate-
dc.subject.keywordAuthornanoparticle-
dc.subject.keywordAuthoradriamycin-
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KIST Article > 2000
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