Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, KY | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Kwon, IC | - |
dc.contributor.author | Jeong, SY | - |
dc.date.accessioned | 2024-01-21T13:09:05Z | - |
dc.date.available | 2024-01-21T13:09:05Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2000-12 | - |
dc.identifier.issn | 0303-402X | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/140906 | - |
dc.description.abstract | A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregated suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2). | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG | - |
dc.subject | BLOCK-COPOLYMER MICELLES | - |
dc.subject | HYDROGEL NANOPARTICLE | - |
dc.subject | PHYSICAL ENTRAPMENT | - |
dc.subject | DELIVERY | - |
dc.subject | DRUG | - |
dc.subject | STABILIZATION | - |
dc.subject | COMPLEXATION | - |
dc.subject | DERIVATIVES | - |
dc.subject | BLOOD | - |
dc.title | Self-aggregates of deoxycholic acid modified chitosan as a novel carrier of adriamycin | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s003960000389 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | COLLOID AND POLYMER SCIENCE, v.278, no.12, pp.1216 - 1219 | - |
dc.citation.title | COLLOID AND POLYMER SCIENCE | - |
dc.citation.volume | 278 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1216 | - |
dc.citation.endPage | 1219 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000166036800012 | - |
dc.identifier.scopusid | 2-s2.0-0033638749 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | HYDROGEL NANOPARTICLE | - |
dc.subject.keywordPlus | PHYSICAL ENTRAPMENT | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | STABILIZATION | - |
dc.subject.keywordPlus | COMPLEXATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | deoxycholic acid | - |
dc.subject.keywordAuthor | self-aggregate | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | adriamycin | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.