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dc.contributor.authorChoo, HYP-
dc.contributor.authorPeak, KH-
dc.contributor.authorPark, J-
dc.contributor.authorKim, DH-
dc.contributor.authorChung, HS-
dc.date.accessioned2024-01-21T14:03:38Z-
dc.date.available2024-01-21T14:03:38Z-
dc.date.created2021-09-05-
dc.date.issued2000-06-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/141359-
dc.description.abstractThe alpha,beta-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly. (C) 2000 Editions scientifiques et medicales Elsevier SAS.-
dc.languageEnglish-
dc.publisherEDITIONS SCIENTIFIQUES MEDICALES ELSEVIER-
dc.subjectANGIOTENSIN-CONVERTING ENZYME-
dc.subjectANTIHYPERTENSIVE AGENTS-
dc.subjectCARBOXYPEPTIDASE-A-
dc.subjectACIDS-
dc.titleDesign and synthesis of alpha,beta-unsaturated carbonyl compounds as potential ACE inhibitors-
dc.typeArticle-
dc.identifier.doi10.1016/S0223-5234(00)00158-6-
dc.description.journalClass1-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.35, no.6, pp.643 - 648-
dc.citation.titleEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY-
dc.citation.volume35-
dc.citation.number6-
dc.citation.startPage643-
dc.citation.endPage648-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000088599700008-
dc.identifier.scopusid2-s2.0-0033947207-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusANGIOTENSIN-CONVERTING ENZYME-
dc.subject.keywordPlusANTIHYPERTENSIVE AGENTS-
dc.subject.keywordPlusCARBOXYPEPTIDASE-A-
dc.subject.keywordPlusACIDS-
dc.subject.keywordAuthoralpha,beta-unsaturated amides-
dc.subject.keywordAuthorangiotensin converting enzyme inhibitor irreversible inhibitors-
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