Palladium-catalyzed coupling reaction of iodouracil having acetamidine moiety with olefins

Abstract

The reaction of 6-[1-Aza-2-(dimethylamino)prop-1-enyl]-5-iodo-1,3-dimethyluracil (3) with various olefins in the presence of a catalytic amount of Pd(OAc)(2) and 1.5 equiv. of K2CO3 in DMF at 120 degrees C gave the pyrido[2,3-d]pyrimidine derivatives (5a-b and 7a-d) in moderate to high yield.