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3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis

Authors: Pae, AN; Kim, SY; Kim, HY; Joo, HJ; Cho, YS; Choi, KI; Choi, JH; Koh, HY

Issue Date: 1999-09-20

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.9, no.18, pp.2685 - 2690

Abstract: Three-dimensional QSAR studies for two series of new oxazolidinone antibacterial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-resistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation with their steric, electrostatic factors and lipophilicities. (C) 1999 Elsevier Science Ltd. All rights reserved.

Keywords: QSAR

ISSN: 0960-894X

URI: https://pubs.kist.re.kr/handle/201004/141906

DOI: 10.1016/S0960-894X(99)00474-6

Appears in Collections:: KIST Article > Others

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