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dc.contributor.authorSong, CE-
dc.contributor.authorOh, CR-
dc.contributor.authorRoh, EJ-
dc.contributor.authorLee, SG-
dc.contributor.authorChoi, JH-
dc.date.accessioned2024-01-21T15:45:04Z-
dc.date.available2024-01-21T15:45:04Z-
dc.date.created2021-09-04-
dc.date.issued1999-02-26-
dc.identifier.issn0957-4166-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/142389-
dc.description.abstractA highly enantioselective (up to 97% ee) one-step synthesis of paclitaxel side chain precursor, (2R,3S)-isopropyl 3-benzamido-2-hydroxy-3-phenylpropionate has been achieved by osmium-catalyzed asymmetric aminohydroxylation of isopropyl trans-cinnamate with N-bromobenzamide as an oxidant/nitrogen source in the presence of (DHQ)(2)PHAL as a chiral ligand. Simple recrystallization of crude product (containing regioisomer and diol) from ethyl acetate gave the enantiomerically pure product. (C) 1999 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectTAXOL-
dc.titleOne-step synthesis of paclitaxel side-chain precursor: benzamide-based asymmetric aminohydroxylation of isopropyl trans-cinnamate-
dc.typeArticle-
dc.identifier.doi10.1016/S0957-4166(99)00040-3-
dc.description.journalClass1-
dc.identifier.bibliographicCitationTETRAHEDRON-ASYMMETRY, v.10, no.4, pp.671 - 674-
dc.citation.titleTETRAHEDRON-ASYMMETRY-
dc.citation.volume10-
dc.citation.number4-
dc.citation.startPage671-
dc.citation.endPage674-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000079748200005-
dc.identifier.scopusid2-s2.0-0000715987-
dc.relation.journalWebOfScienceCategoryChemistry, Inorganic & Nuclear-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusTAXOL-
dc.subject.keywordAuthorpaclitaxel side chain-
dc.subject.keywordAuthorasymmetric aminohydroxylation-
dc.subject.keywordAuthoranti-cancer drugs-
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