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dc.contributor.authorChun, MW-
dc.contributor.authorOlmstead, KK-
dc.contributor.authorChoi, Y-
dc.contributor.authorLee, CO-
dc.contributor.authorLee, CK-
dc.contributor.authorKim, JH-
dc.contributor.authorLee, L-
dc.date.accessioned2024-01-21T16:44:25Z-
dc.date.available2024-01-21T16:44:25Z-
dc.date.created2021-09-03-
dc.date.issued1998-08-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/142934-
dc.description.abstractA series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxyquinolone showed potent antitumor activity (IC50=17.7 mu M for HL60) which was greater than that of acronycine. However, these compounds didn't show any significant antiherpes or antituberculosis activity.-
dc.languageEnglish-
dc.publisherPHARMACEUTICAL SOCIETY KOREA-
dc.titleSynthesis and biological activity of 5-hydroxy-4-quinolones and 5-methoxy-4-quinolones as truncated acridones-
dc.typeArticle-
dc.identifier.doi10.1007/BF02974641-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.21, no.4, pp.445 - 451-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume21-
dc.citation.number4-
dc.citation.startPage445-
dc.citation.endPage451-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000075325000015-
dc.identifier.scopusid2-s2.0-0032130769-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusASSAY-
dc.subject.keywordPlusALKALOIDS-
dc.subject.keywordPlusSERIES-
dc.subject.keywordAuthoracridone-
dc.subject.keywordAuthor5-hydroxy-4-quinolone-
dc.subject.keywordAuthor5-methoxy-4-quinolone-
dc.subject.keywordAuthorantitumor activity-
dc.subject.keywordAuthorantiherpes activity-
dc.subject.keywordAuthorantituberculosis activity-
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