Synthesis of a cyclic urea as a nonnatural biopolymer scaffold

Abstract

A cyclic urea trimer was synthesized from readily available amino acid derivatives using a simple, iterative approach. A selective amide reduction using borane (BH3-THF) and a triphosgens-mediated cyclization are the key features in a synthesis of the cyclic urea trimer 2. Copyright (C) 1996 Elsevier Science Ltd