IODOACETONITRILE AND BROMOACETONITRILE AS ALKYLATING REAGENTS FOR THE NITROGEN PHOSPHORUS DETECTOR

Abstract

Iodoacetonitrile and bromoacetonitrile were used to enhance the sensitivity of chromatographically difficult compounds. Selective derivatization occurs with acidic hydroxyl, amino, and amide functional groups but does not occur for the alcoholic hydroxyl group. Numerous examples of model compounds (e.g,, phenols, organic acids, fatty acids, nonsteroidal antiinflammatory drugs, and xanthines) are given, The use of an element-specific detector for nitrogen-containing compounds is described, and some electron impact GC/MS data are provided for the derivatized model compounds.