KDS2010, a reversible MAO-B inhibitor, extends the lifetime of neural probes by preventing glial scar formation

Authors
Chae, UikyuChun, HeejungLim, JiwoonShin, HyogeunSmith, Wesley CharlesChoi, Ji WonPark, Ki DukLee, C. JustinCho, Il-Joo
Issue Date
2024-01
Publisher
John Wiley & Sons Inc.
Citation
GLIA
Abstract
Implantable neural probes have been extensively utilized in the fields of neurocircuitry, systems neuroscience, and brain-computer interface. However, the long-term functionality of these devices is hampered by the formation of glial scar and astrogliosis at the surface of electrodes. In this study, we administered KDS2010, a recently developed reversible MAO-B inhibitor, to mice through ad libitum drinking in order to prevent glial scar formation and astrogliosis. The administration of KDS2010 allowed long-term recordings of neural signals with implantable devices, which remained stable over a period of 6 months and even restored diminished neural signals after probe implantation. KDS2010 effectively prevented the formation of glial scar, which consists of reactive astrocytes and activated microglia around the implant. Furthermore, it restored neural activity by disinhibiting astrocytic MAO-B dependent tonic GABA inhibition induced by astrogliosis. We suggest that the use of KDS2010 is a promising approach to prevent glial scar formation around the implant, thereby enabling long-term functionality of neural devices.
Keywords
BRAIN-TISSUE; RESPONSES; astrogliosis; glial scar; implantable neural probes; MAO-B inhibitor
ISSN
0894-1491
URI
https://pubs.kist.re.kr/handle/201004/148594
DOI
10.1002/glia.24500
Appears in Collections:
KIST Article > 2024
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE