Self-assembled peptoid hydrogel as biomaterial ink

Abstract

Peptoids are bio-inspired and sequence-defined oligomers that can besynthesized by the solid-phase submonomer method using diverseamine synthons. Peptoid sequences govern non-covalent interactionswithin the peptoid strand and between them. Therefore, peptoidchemistry has facilitated the exploration of diverse peptoid sequencesas building blocks to create multi-dimensional nanomaterials such asnanospheres, nanotubes, nanofibers, and nanosheets via selfassemblyprocess. In this talk, I will present self-assembled peptoidhydrogels as biomaterial ink. The hydrogel is a 3-dimensional networkformed by connecting nanosheets that are spontaneously organizedbetween peptoid strands through π？π and hydrophobic interactions.Rheological studies demonstrated that peptoid hydrogels exhibitshear-thinning, self-healing, and stress-relaxation abilities, makingthem suitable for use as injectable and sprayable hydrogels. Furthermore,the peptoid hydrogel functions effectively as a biomimetic scaffoldwith excellent biocompatibility, capable of modulatingphysiological activity through the incorporation of cell-adhesive RGDpeptide at the end of the peptoid sequence. Overall, I anticipate thatself-assembled peptoid hydrogels hold promise for next-generationbiomedical applications.