Minor red blood cell antigen phenotyping of athletes sampled in international competitions

Authors
Cristina Mirotti, LucianaRenovato­ Martins, MarianaDu Rocher­Silva, B?rbaraDudenhoeffer­Carneiro, Ana CarolinaSoares, FelipeRahaman, Khandoker AsiqurHasan, MahbubMuresan, Anca RalucaKwon, Oh­SeungSon, Junghyun JohnPereira, Henrique Marcelo Gualberto
Issue Date
2023-03
Publisher
John Wiley & Sons Ltd.
Citation
Drug Testing and Analysis, v.15, no.3, pp.292 - 298
Abstract
Blood transfusion is performed by cheating athletes to rapidly increase oxygen delivery to exercise muscles and enhance their performance. This method is banned by the World Anti-doping Agency (WADA). Heterologous or allogenic blood transfusion happens when blood from a different person is transfused. The method used to detect this type of doping is based on flow cytometry, by identifying variations in blood group minor antigens present on the red blood cells' surface. Transfusion practices have regained interest since the introduction of human recombinant erythropoietin detection method. It has been reported that the number of occurrences of two athletes sharing an identical phenotype in the same sport was five times higher than the theoretical populational probability. The present work describes the prevalence of 10 erythrocytes surface antigens in a population of 261 athletes from all five continents. The matching phenotype per sport is also described.
Keywords
athletes; blood doping; flow cytometry; homologous blood transfusion; red blood cell antigens
ISSN
1942-7603
URI
https://pubs.kist.re.kr/handle/201004/75788
DOI
10.1002/dta.3402
Appears in Collections:
KIST Article > 2023
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