Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung-Hwan | - |
dc.contributor.author | Park, Tae-Jin | - |
dc.contributor.author | Park, Jin-Soo | - |
dc.contributor.author | Kim, MinSeon | - |
dc.contributor.author | Chi, Won-Jae | - |
dc.contributor.author | Kim, Seung-Young | - |
dc.date.accessioned | 2024-01-12T03:32:59Z | - |
dc.date.available | 2024-01-12T03:32:59Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/76816 | - |
dc.description.abstract | Luteolin (LT), present in most plants, has potent anti-inflammatory properties both in vitro and in vivo. Furthermore, some of its derivatives, such as luteolin-7-O-glucoside, also exhibit anti-inflammatory activity. However, the molecular mechanisms underlying luteolin-3 PRIME;-O-phosphate (LTP)-mediated immune regulation are not fully understood. In this paper, we compared the anti-inflammatory properties of LT and LTP and analyzed their molecular mechanisms of action; we obtained LTP via the biorenovation of LT. We investigated the anti-inflammatory activities of LT and LTP in macrophage RAW 264.7 cells. We confirmed from previously reported literature that LT inhibits the production of nitric oxide and prostaglandin E-2, as well as the expression of inducible NO synthetase and cyclooxygenase-2. In addition, expressions of inflammatory genes and mediators, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta, were suppressed. LTP showed anti-inflammatory activity similar to LT, but better anti-inflammatory activity in all the experiments, while also inhibiting mitogen-activated protein kinase and nuclear factor-kappa B more effectively than LT. At a concentration of 10 mu M, LTP showed differences of 2.1 to 44.5% in the activity compared to LT; it also showed higher anti-inflammatory activity. Our findings suggest that LTP has stronger anti-inflammatory activity than LT. | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Luteolin-3'-O-Phosphate Inhibits Lipopolysaccharide-Induced Inflammatory Responses by Regulating NF-kappa B/MAPK Cascade Signaling in RAW 264.7 Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/molecules26237393 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Molecules, v.26, no.23 | - |
dc.citation.title | Molecules | - |
dc.citation.volume | 26 | - |
dc.citation.number | 23 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000734579300001 | - |
dc.identifier.scopusid | 2-s2.0-85121119438 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | LUTEOLIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | luteolin-3 &apos | - |
dc.subject.keywordAuthor | -O-phosphate | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | biorenovation | - |
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