The study of antibiotic drug-loaded polymer films for the prevention of the infection of external fixation devices

Lee, Moon KyuLee, ChangyangKim, Dong RyulKwon, Ik ChanChoi, Kuiwon
Issue Date
7th Asian Symposium on Biomedical Materials (ASBM7), v.342-343, pp.533 - +
The purpose of the present study was to develop a polymer film loaded with drug to effectively prevent pin tract infection. It was found that the polymer, poly ethylene-co-vinyl acetate blended with tetrahydrofuran, showed better flexibility and deformability than the other polymers: poly caprolactone18 and poly caprolactone44. Polymer films, poly ethylene-co-vinyl acetate, were divided into five testing groups dependent on the loading concentration of rifampici (5, 10, 15, and 20 wt %). The surface morphology of polymer films was examined by a scanning electron microscopy. It was found that the concentration of drug was a main factor to determine the roughness of the film. Considering the roughness of polymer films, 5 wt %, of rifampicin might be the maximum concentration for further applications. Hence, the antibiotic drug-loaded polymer Films were manufactured by mixing poly(ethylene-co-vinylacetate) and tetrahydrofuran with rifampicin(antibiotic drug). The film cast was designed as a shape of disk (inner phi 5mm and outer phi\20mm) to be suitable for pins for external fixation in orhtopaedics. The drug-loaded polymer solvent. the amount of 0.6cc, was molded into the disk-shaped film and dried into a airtight box at 15 degrees C for 24 hrs. The drug release characteristics(1, 2, 3, 4 and 5 wt%) were examined as a function of soaking time in phosphate buffered saline (PBS, 10 ml) using an enzyme-linked immunosorbent assay. Rifampicin was linearly released for first 100 hrs(similar to 4 days) for all antibiotic drug-loaded Polymer films. Afterward, the drug was released at a slower pace as a function of square root of time until 1000 hrs (similar to 40 days). This slow drug release can be explained by their hydrophobic characteristics of poly ethylene-co-vinyl acetate and rifampicin. The antibiotic drug-loaded polymer film can be intrinsically able to prevent the bacteria adhesion by wrapping the pin track area, and perform active and effective infection-resistant by a sustained antibiotic-release.
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KIST Conference Paper > 2007
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