Silica Nanodepletors: Targeting and Clearing Alzheimer's beta-Amyloid Plaques

Authors
Jung, HuijinChung, You JungWilton, RosemarieLee, Chang HeonLee, Byung IlLim, JinyeongLee, HyojinChoi, Jong-HoKang, HyunoLee, ByeongduRozhkova, Elena A.Park, Chan BeumLee, Joonseok
Issue Date
2020-04
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED FUNCTIONAL MATERIALS, v.30, no.15
Abstract
Abnormal accumulation of beta-amyloid (A beta) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). A beta aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress A beta aggregate formation, thereby attenuating A beta-induced neurotoxicity. Here, the design of A beta nanodepletors consisting of ultralarge mesoporous silica nanostructures and anti-A beta single-chain variable fragments, with the goal of targeting and eliminating aggregative A beta monomers, is reported. The A beta nanodepletors impart a notable decline in A beta aggregate formation, resulting in significant mitigation of A beta-induced neurotoxicity in vitro. Furthermore, stereotaxic injections of A beta nanodepletors into the brain of an AD mouse model system successfully suppress A beta plaque formation in vivo up to approximate to 30%, suggesting that A beta nanodepletors can serve as a promising antiamylodoisis material.
Keywords
BLOOD-BRAIN-BARRIER; PROTEIN AGGREGATION; IN-VITRO; DISEASE; NEURODEGENERATION; NANOPARTICLES; MECHANISM; PEPTIDES; FIBRILS; DECLINE; beta-amyloid peptides; Alzheimer' s disease; nanodepletors; scFv; silica nanostructures
ISSN
1616-301X
URI
https://pubs.kist.re.kr/handle/201004/118791
DOI
10.1002/adfm.201910475
Appears in Collections:
KIST Article > 2020
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE