An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
- Authors
- Kwon, Jaeyoung; Ko, Keebeom; Zhang, Lijun; Zhao, Dong; Yang, Hyun Ok; Kwon, Hak Cheol
- Issue Date
- 2019-12
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Citation
- Molecules, v.24, no.24
- Abstract
- Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson's disease through autophagy induction.
- Keywords
- CONSTITUENTS; DISEASE; HEALTH; Aster koraiensis; triterpene saponin; autophagy; natural products
- ISSN
- 1420-3049
- URI
- https://pubs.kist.re.kr/handle/201004/119288
- DOI
- 10.3390/molecules24244489
- Appears in Collections:
- KIST Article > 2019
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