An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis

Authors
Kwon, JaeyoungKo, KeebeomZhang, LijunZhao, DongYang, Hyun OkKwon, Hak Cheol
Issue Date
2019-12
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Citation
Molecules, v.24, no.24
Abstract
Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson's disease through autophagy induction.
Keywords
CONSTITUENTS; DISEASE; HEALTH; Aster koraiensis; triterpene saponin; autophagy; natural products
ISSN
1420-3049
URI
https://pubs.kist.re.kr/handle/201004/119288
DOI
10.3390/molecules24244489
Appears in Collections:
KIST Article > 2019
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