DSpace at KIST: Cytotoxic constituents from the roots of asarum sieboldii in human breast cancer cells

Cytotoxic constituents from the roots of asarum sieboldii in human breast cancer cells

Authors: Kim, E.; Kim, H.J.; Oh, H.-N.; Kwak, A.-W.; Kim, S.-N.; Kang, B.Y.; Cho, S.-S.; Shim, J.-H.; Yoon, G.

Abstract: Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC50 values of 9.15 and 13.95 ？M, respectively. ？ 2019, Korean Society of Pharmacognosy. All rights reserved.

Keywords: 2e,4e,8z,10e n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide; 2e,4e,8z,10z n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide; asarinin; Asarum sieboldii extract; fluorouracil; methylkakuol; plant extract; sesamin; unclassified drug; xanthoxylol; antineoplastic activity; Article; Asarum sieboldii; breast cancer; carbon nuclear magnetic resonance; cell viability; chemical structure; controlled study; cytotoxicity; drug synthesis; human; human cell; IC50; infrared spectroscopy; MCF-7 cell line; MDA-MB-231 cell line; medicinal plant; MTT assay; proton nuclear magnetic resonance; 2e,4e,8z,10e n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide; 2e,4e,8z,10z n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide; asarinin; Asarum sieboldii extract; fluorouracil; methylkakuol; plant extract; sesamin; unclassified drug; xanthoxylol; antineoplastic activity; Article; Asarum sieboldii; breast cancer; carbon nuclear magnetic resonance; cell viability; chemical structure; controlled study; cytotoxicity; drug synthesis; human; human cell; IC50; infrared spectroscopy; MCF-7 cell line; MDA-MB-231 cell line; medicinal plant; MTT assay; proton nuclear magnetic resonance; Asarum sieboldii; Breast cancer; Cytotoxicity; Xanthoxylol

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