MIR-27a regulates the TGF- signaling pathway by targeting SMAD2 and SMAD4 in lung cancer

Authors
Chae, Dong-KyuBan, EunmiYoo, Young SookKim, Eunice EunKyeongBaik, Ja-HyunSong, Eun Joo
Issue Date
2017-08
Publisher
WILEY
Citation
MOLECULAR CARCINOGENESIS, v.56, no.8, pp.1992 - 1998
Abstract
The transforming growth factor- (TGF-) signaling pathway is associated with carcinogenesis and various biological processes. SMAD2 and SMAD4, which are putative tumor suppressors, have an important role in TGF- signaling. The aberrant expression of these genes is implicated in some cancers. However, the mechanisms of SMAD2 and SMAD4 dysregulation are poorly understood. In this study, we observed that miR-27a was upregulated in lung cancer cell lines and patients. In addition, SMAD2 and SMAD4 genes were identified as targets of miR-27a by several target prediction databases and experimental validation. Functional studies revealed that miR-27a overexpression decreased SMAD2 and SMAD4 mRNA and protein levels. Furthermore, miR-27a contributed to cell proliferation and invasion by inhibiting TGF--induced cell cycle arrest. These results suggest that miR-27a may function as an oncogene by regulating SMAD2 and SMAD4 in lung cancer. Thus, miR-27a may be a potential target for cancer therapy.
Keywords
MICRORNA-27A FUNCTIONS; TUMOR-SUPPRESSOR; PROGRESSION; CARCINOMA; CELLS; MICRORNA-27A FUNCTIONS; TUMOR-SUPPRESSOR; PROGRESSION; CARCINOMA; CELLS; lung cancer; miR-27a; SMAD2; SMAD4; TGF-
ISSN
0899-1987
URI
https://pubs.kist.re.kr/handle/201004/122499
DOI
10.1002/mc.22655
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KIST Article > 2017
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