Neuron-Material Nanointerfaces: Surface Nanotopography Governs Neuronal Differentiation and Development

Authors
Kim, Hoon KeeKim, EunhaJang, HongjeKim, Young-KwanKang, Kyungtae
Issue Date
2017-05
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMNANOMAT, v.3, no.5, pp.278 - 287
Abstract
This review summarizes recent experimental results regarding the influences of surface nanotopography on stem cell differentiation into neurons and neuronal development. Collections of observations and their interpretations are provided. We specifically focus on the in vivo implications of the results, by suggesting that: (i) neural cells use their intracellular machineries to actively recognize surface nanotopography; (ii) the preferential differentiation of stem cells into neurons and the developmental acceleration of neurons occur on a range of similar nanotopographical features, implying that they have similar biological backgrounds; and (iii) surface nanotopography, therefore, is deeply involved in brain development. We believe that this review will provide biological insights to the field of nanoneuron interfaces and encourage interdisciplinary efforts capable of addressing unsolved biological problems and increasing engineering needs.
Keywords
EMBRYONIC STEM-CELLS; FOCAL ADHESION KINASE; NERVE GROWTH-FACTOR; NEURITE OUTGROWTH; EXTRACELLULAR-MATRIX; HIPPOCAMPAL-NEURONS; SILICON NANOWIRES; CONTACT GUIDANCE; IN-VITRO; TOPOGRAPHY; EMBRYONIC STEM-CELLS; FOCAL ADHESION KINASE; NERVE GROWTH-FACTOR; NEURITE OUTGROWTH; EXTRACELLULAR-MATRIX; HIPPOCAMPAL-NEURONS; SILICON NANOWIRES; CONTACT GUIDANCE; IN-VITRO; TOPOGRAPHY; cell adhesion; nanostructures; neurite development; neurochemistry; stem cell differentiation
ISSN
2199-692X
URI
https://pubs.kist.re.kr/handle/201004/122815
DOI
10.1002/cnma.201700063
Appears in Collections:
KIST Article > 2017
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