Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model
- Authors
- Jo, Seongil; Woo, Hae Dong; Kwon, Ho-Jang; Oh, Se-Young; Park, Jung-Duck; Hong, Young-Seoub; Pyo, Heesoo; Park, Kyung Su; Ha, Mina; Kim, Ho; Sohn, Seok-Joon; Kim, Yu-Mi; Lim, Ji-Ae; Lee, Sang-Ah; Eom, Sang-Yong; Kim, Byoung-Gwon; Lee, Kyoung-Mu; Lee, Jong-Hyeon; Hwang, Myung Sil; Kim, Jeongseon
- Issue Date
- 2015-08
- Publisher
- MDPI AG
- Citation
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.12, no.8, pp.9054 - 9067
- Abstract
- Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 +/- 8.6 days. The population mean of the methylmercury half-life was 81.6 +/- 8.4 days for men and 78.9 +/- 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 +/- 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values.
- Keywords
- POLYUNSATURATED FATTY-ACIDS; METHYL MERCURY; FISH CONSUMPTION; BLOOD; EXPOSURE; HUMANS; HAIR; VARIABILITY; INGESTION; POLYUNSATURATED FATTY-ACIDS; METHYL MERCURY; FISH CONSUMPTION; BLOOD; EXPOSURE; HUMANS; HAIR; VARIABILITY; INGESTION; biological half-life; dietary exposure; methylmercury; one-compartment toxicokinetic model; population model
- ISSN
- 1661-7827
- URI
- https://pubs.kist.re.kr/handle/201004/125194
- DOI
- 10.3390/ijerph120809054
- Appears in Collections:
- KIST Article > 2015
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