Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives
- Authors
- Kim, Youngjae; Kim, Minjoo; Park, Mooseong; Tae, Jinsung; Baek, Du-Jong; Park, Ki Duk; Choo, Hyunah
- Issue Date
- 2015-03
- Publisher
- MDPI AG
- Citation
- MOLECULES, v.20, no.3, pp.5074 - 5084
- Abstract
- A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
- Keywords
- MGLUR1 ANTAGONISTS; CLOPIDOGREL; PAIN; MGLUR1 ANTAGONISTS; CLOPIDOGREL; PAIN; Dihydropyridothienopyrimidin-4,9-dione; Pyridothienopyrimidine; Successive ring formation
- ISSN
- 1420-3049
- URI
- https://pubs.kist.re.kr/handle/201004/125711
- DOI
- 10.3390/molecules20035074
- Appears in Collections:
- KIST Article > 2015
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