Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives

Authors
Kim, YoungjaeKim, MinjooPark, MooseongTae, JinsungBaek, Du-JongPark, Ki DukChoo, Hyunah
Issue Date
2015-03
Publisher
MDPI AG
Citation
MOLECULES, v.20, no.3, pp.5074 - 5084
Abstract
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
Keywords
MGLUR1 ANTAGONISTS; CLOPIDOGREL; PAIN; MGLUR1 ANTAGONISTS; CLOPIDOGREL; PAIN; Dihydropyridothienopyrimidin-4,9-dione; Pyridothienopyrimidine; Successive ring formation
ISSN
1420-3049
URI
https://pubs.kist.re.kr/handle/201004/125711
DOI
10.3390/molecules20035074
Appears in Collections:
KIST Article > 2015
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