KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model

Authors
Li, HailanKim, JandiHahn, Hoh-GyuYun, JunJeong, Hyo-SoonYun, Hye-YoungBaek, Kwang JinKwon, Nyoun SooMin, Young SilPark, Kyoung-ChanKim, Dong-Seok
Issue Date
2014-06
Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.18, no.3, pp.249 - 254
Abstract
The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase, the rate-limiting enzyme in melanogenesis, although tyrosinase was not inhibited directly. KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation. These results suggest that KHG26792 decreases melanin production via ERK activation. Moreover, the hypopiginentary effects of KHG26792 were confirmed in a pigmented skin equivalent model using Cervi comas Colla (deer antler glue), in which the color of the pigmented artificial skin became lighter after treatment with KHG26792. In summary, our findings suggest that KHG26792 is a novel skin whitening agent.
Keywords
HUMAN MELANOCYTES; ERK ACTIVATION; IN-VITRO; PIGMENTATION; MELANOGENESIS; TYROSINASE; HUMAN MELANOCYTES; ERK ACTIVATION; IN-VITRO; PIGMENTATION; MELANOGENESIS; TYROSINASE; ERK; KHG26792; Melanogenesis; Skin equivalent; Tyrosinase
ISSN
1226-4512
URI
https://pubs.kist.re.kr/handle/201004/126756
DOI
10.4196/kjpp.2014.18.3.249
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KIST Article > 2014
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