Structured Synaptic Connectivity between Hippocampal Regions
- Authors
- Druckmann, Shaul; Feng, Linqing; Lee, Bokyoung; Yook, Chaehyun; Zhao, Ting; Magee, Jeffrey C.; Kim, Jinhyun
- Issue Date
- 2014-02-05
- Publisher
- CELL PRESS
- Citation
- NEURON, v.81, no.3, pp.629 - 640
- Abstract
- The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
- Keywords
- CA1 PYRAMIDAL NEURONS; IN-VIVO; CORTICAL-NEURONS; RAT; DENDRITES; CELLS; INTEGRATION; MULTIPLE; INPUTS; ORGANIZATION; CA1 PYRAMIDAL NEURONS; IN-VIVO; CORTICAL-NEURONS; RAT; DENDRITES; CELLS; INTEGRATION; MULTIPLE; INPUTS; ORGANIZATION
- ISSN
- 0896-6273
- URI
- https://pubs.kist.re.kr/handle/201004/127103
- DOI
- 10.1016/j.neuron.2013.11.026
- Appears in Collections:
- KIST Article > 2014
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