Structured Synaptic Connectivity between Hippocampal Regions

Authors
Druckmann, ShaulFeng, LinqingLee, BokyoungYook, ChaehyunZhao, TingMagee, Jeffrey C.Kim, Jinhyun
Issue Date
2014-02-05
Publisher
CELL PRESS
Citation
NEURON, v.81, no.3, pp.629 - 640
Abstract
The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
Keywords
CA1 PYRAMIDAL NEURONS; IN-VIVO; CORTICAL-NEURONS; RAT; DENDRITES; CELLS; INTEGRATION; MULTIPLE; INPUTS; ORGANIZATION; CA1 PYRAMIDAL NEURONS; IN-VIVO; CORTICAL-NEURONS; RAT; DENDRITES; CELLS; INTEGRATION; MULTIPLE; INPUTS; ORGANIZATION
ISSN
0896-6273
URI
https://pubs.kist.re.kr/handle/201004/127103
DOI
10.1016/j.neuron.2013.11.026
Appears in Collections:
KIST Article > 2014
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