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dc.contributor.authorHan, Hyojeong-
dc.contributor.authorSeo, Hong Seog-
dc.contributor.authorJung, Byung Hwa-
dc.contributor.authorWoo, Kyoungja-
dc.contributor.authorYoo, Young Sook-
dc.contributor.authorKang, Min-Jung-
dc.date.accessioned2024-01-20T11:00:22Z-
dc.date.available2024-01-20T11:00:22Z-
dc.date.created2021-09-05-
dc.date.issued2014-01-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127296-
dc.description.abstractSubstance P and neuropeptide Y were-discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.-
dc.languageEnglish-
dc.publisher대한화학회-
dc.titleSubstance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2014.35.1.158-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBulletin of the Korean Chemical Society, v.35, no.1, pp.158 - 164-
dc.citation.titleBulletin of the Korean Chemical Society-
dc.citation.volume35-
dc.citation.number1-
dc.citation.startPage158-
dc.citation.endPage164-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001846048-
dc.identifier.wosid000330682100026-
dc.identifier.scopusid2-s2.0-84892903136-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCREATINE-KINASE-MB-
dc.subject.keywordPlusHEART-FAILURE-
dc.subject.keywordPlusNATRIURETIC PEPTIDE-
dc.subject.keywordPlusTROPONIN ASSAYS-
dc.subject.keywordPlusNT-PROBNP-
dc.subject.keywordPlusMYOGLOBIN-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusMARKERS-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusPAIN-
dc.subject.keywordAuthorSubstance P-
dc.subject.keywordAuthorNeuropeptide Y-
dc.subject.keywordAuthorBiomarker-
dc.subject.keywordAuthorAcute myocardial infarction-
dc.subject.keywordAuthorLC-MS-
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KIST Article > 2014
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