Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Han, Hyojeong | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Jung, Byung Hwa | - |
dc.contributor.author | Woo, Kyoungja | - |
dc.contributor.author | Yoo, Young Sook | - |
dc.contributor.author | Kang, Min-Jung | - |
dc.date.accessioned | 2024-01-20T11:00:22Z | - |
dc.date.available | 2024-01-20T11:00:22Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/127296 | - |
dc.description.abstract | Substance P and neuropeptide Y were-discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI. | - |
dc.language | English | - |
dc.publisher | 대한화학회 | - |
dc.title | Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.5012/bkcs.2014.35.1.158 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.35, no.1, pp.158 - 164 | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 158 | - |
dc.citation.endPage | 164 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.identifier.kciid | ART001846048 | - |
dc.identifier.wosid | 000330682100026 | - |
dc.identifier.scopusid | 2-s2.0-84892903136 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CREATINE-KINASE-MB | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.subject.keywordPlus | NATRIURETIC PEPTIDE | - |
dc.subject.keywordPlus | TROPONIN ASSAYS | - |
dc.subject.keywordPlus | NT-PROBNP | - |
dc.subject.keywordPlus | MYOGLOBIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordAuthor | Substance P | - |
dc.subject.keywordAuthor | Neuropeptide Y | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Acute myocardial infarction | - |
dc.subject.keywordAuthor | LC-MS | - |
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