Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Authors
Han, HyojeongSeo, Hong SeogJung, Byung HwaWoo, KyoungjaYoo, Young SookKang, Min-Jung
Issue Date
2014-01
Publisher
대한화학회
Citation
Bulletin of the Korean Chemical Society, v.35, no.1, pp.158 - 164
Abstract
Substance P and neuropeptide Y were-discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.
Keywords
CREATINE-KINASE-MB; HEART-FAILURE; NATRIURETIC PEPTIDE; TROPONIN ASSAYS; NT-PROBNP; MYOGLOBIN; DISEASE; MARKERS; BRAIN; PAIN; Substance P; Neuropeptide Y; Biomarker; Acute myocardial infarction; LC-MS
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/127296
DOI
10.5012/bkcs.2014.35.1.158
Appears in Collections:
KIST Article > 2014
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