Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients
- Authors
- Han, Hyojeong; Seo, Hong Seog; Jung, Byung Hwa; Woo, Kyoungja; Yoo, Young Sook; Kang, Min-Jung
- Issue Date
- 2014-01
- Publisher
- 대한화학회
- Citation
- Bulletin of the Korean Chemical Society, v.35, no.1, pp.158 - 164
- Abstract
- Substance P and neuropeptide Y were-discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.
- Keywords
- CREATINE-KINASE-MB; HEART-FAILURE; NATRIURETIC PEPTIDE; TROPONIN ASSAYS; NT-PROBNP; MYOGLOBIN; DISEASE; MARKERS; BRAIN; PAIN; Substance P; Neuropeptide Y; Biomarker; Acute myocardial infarction; LC-MS
- ISSN
- 0253-2964
- URI
- https://pubs.kist.re.kr/handle/201004/127296
- DOI
- 10.5012/bkcs.2014.35.1.158
- Appears in Collections:
- KIST Article > 2014
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