Aldose reductase inhibitory compounds from extracts of Dipsacus asper

Authors
Koo, Dong ChilBaek, So YoonJung, Sang HoonShim, Sang Hee
Issue Date
2013-09
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Citation
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.18, no.5, pp.926 - 931
Abstract
Amethanolic extract of Dipsacus asper, having anti-diabetic activity, was examined as a possible aldose reductase (ALR2) inhibitor, a key enzyme involved in diabetic complications. Bioactivity guided fractionation led to the isolation of ten compounds, ursolic acid (1), oleanolic acid-3-O-alpha-L-arabinopyranoside (2), daucosterol (3), hederagenin-3-O-alpha-L-arabinopyranoside (4), sweroside(5), caffeic acid (6), esculetin (7), protocatechualdehyde (8), loganin (9), and vanilic acid (10) from the ethyl acetate fraction of D. asper methanol extract. Among them, compounds 4, 6, 7, and 8 exhibited inhibitory effects on aldose reductase, with IC50 values of 23.70, 16.71, 34.36, and 21.81 mu M, respectively. This is the first report on the isolation of these compounds from D. asper, and the ALR2 inhibitory activity of hederagenin-3-O-alpha-L-arabinopyranoside. These results suggest the successful use of the extract of D. asper for ameliorating diabetic complications.
Keywords
STRUCTURAL REQUIREMENTS; DIABETIC-RATS; GLYCATION; LENS; FLAVONOIDS; ACID; STRUCTURAL REQUIREMENTS; DIABETIC-RATS; GLYCATION; LENS; FLAVONOIDS; ACID; Dipsacus asper; aldose reductase; hederagenin-3-O-alpha-L-arabinopyranoside; esculetin
ISSN
1226-8372
URI
https://pubs.kist.re.kr/handle/201004/127731
DOI
10.1007/s12257-013-0173-z
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KIST Article > 2013
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