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dc.contributor.authorKang, Kyungsu-
dc.contributor.authorLee, Kyung-Mi-
dc.contributor.authorYoo, Ji-Hye-
dc.contributor.authorLee, Hee Ju-
dc.contributor.authorKim, Chul Young-
dc.contributor.authorNho, Chu Won-
dc.date.accessioned2024-01-20T13:32:40Z-
dc.date.available2024-01-20T13:32:40Z-
dc.date.created2021-09-04-
dc.date.issued2012-11-16-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128647-
dc.description.abstractHere, we report that gomisin J and gomisin N. clibenzocyclooctadiene type lignans isolated from Sch (sonchinensis, inhibit Wnt/beta-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/Bcatenin signaling by disrupting the interaction between beta-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the beta-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/beta-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/beta-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers. (C) 2012 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectCOLON-CANCER CELLS-
dc.subjectSCHISANDRA-CHINENSIS-
dc.subjectBETA-CATENIN-
dc.subjectSUPPRESSES GROWTH-
dc.subjectACTIVATION-
dc.subjectCOMPONENTS-
dc.subjectAPOPTOSIS-
dc.titleDibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/beta-catenin signaling pathway in HCT116 cells-
dc.typeArticle-
dc.identifier.doi10.1016/j.bbrc.2012.10.046-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.428, no.2, pp.285 - 291-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume428-
dc.citation.number2-
dc.citation.startPage285-
dc.citation.endPage291-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000312431900014-
dc.identifier.scopusid2-s2.0-84869204968-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.type.docTypeArticle-
dc.subject.keywordPlusCOLON-CANCER CELLS-
dc.subject.keywordPlusSCHISANDRA-CHINENSIS-
dc.subject.keywordPlusBETA-CATENIN-
dc.subject.keywordPlusSUPPRESSES GROWTH-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCOMPONENTS-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordAuthorWnt/beta-catenin-
dc.subject.keywordAuthorCancer chemoprevention-
dc.subject.keywordAuthorDibenzocyclooctadiene lignan-
dc.subject.keywordAuthorSchisandra chinensis-
dc.subject.keywordAuthorGomisin-
dc.subject.keywordAuthorCyclin D1-
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