Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/beta-catenin signaling pathway in HCT116 cells
- Authors
- Kang, Kyungsu; Lee, Kyung-Mi; Yoo, Ji-Hye; Lee, Hee Ju; Kim, Chul Young; Nho, Chu Won
- Issue Date
- 2012-11-16
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.428, no.2, pp.285 - 291
- Abstract
- Here, we report that gomisin J and gomisin N. clibenzocyclooctadiene type lignans isolated from Sch (sonchinensis, inhibit Wnt/beta-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/Bcatenin signaling by disrupting the interaction between beta-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the beta-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/beta-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/beta-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers. (C) 2012 Elsevier Inc. All rights reserved.
- Keywords
- COLON-CANCER CELLS; SCHISANDRA-CHINENSIS; BETA-CATENIN; SUPPRESSES GROWTH; ACTIVATION; COMPONENTS; APOPTOSIS; COLON-CANCER CELLS; SCHISANDRA-CHINENSIS; BETA-CATENIN; SUPPRESSES GROWTH; ACTIVATION; COMPONENTS; APOPTOSIS; Wnt/beta-catenin; Cancer chemoprevention; Dibenzocyclooctadiene lignan; Schisandra chinensis; Gomisin; Cyclin D1
- ISSN
- 0006-291X
- URI
- https://pubs.kist.re.kr/handle/201004/128647
- DOI
- 10.1016/j.bbrc.2012.10.046
- Appears in Collections:
- KIST Article > 2012
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